Research Discipline(s): Translational
Primary Title: Professor
Additional Titles & Affiliations: Director of the Histology Services & The Ultrastructural Imaging Platform; Director of the Glioma Cell Resource; Adjunct Scientist, CancerCare Manitoba; Honorary Professor of Shantou University Medical College, Shantou, China; cross-appointed to Depts. of Pathology and Medical Microbiology & Infectious Diseases
RESEARCH TOPICS
Brain Tumors, Primary and Metastatic
Provide hope to patients through innovation
Research Summary
I focus on adult brain tumor patients and women with breast-to-brain metastasis. My goals include (i) the discovery and testing of new drugs that can penetrate the blood-brain barrier, (ii) target and block selected cellular pathways critical for tumor cell survival, and (iii) identify and exploit mechanisms of treatment resistance. My team collaborates with clinical experts create a vibrant translational collaborative research environment with opportunities in undergraduate, graduate, and postgraduate training in brain tumor biology. My research lab is at the forefront of research on C1qTNF related proteins in cancer. My team highlighted an exciting new role of the DNA binding and chromatin remodeling protein HMGA2 (High Mobility Group A2) in PARP1 resistance in breast cancer and collaborates with leading experts to learn about the intricate molecular details of this interaction and effects of HMGA2 targeting for tumor survival. In collaboration with our clinical colleagues and the neighboring Hombach lab, we have generated a new patient-derived HER2+ breast-to-brain metastasis cell and mouse models which we use to identify better treatment options.
Goals
My goals include (i) the discovery and testing of new drugs that can penetrate the blood-brain barrier, (ii) target and block selected cellular pathways critical for tumor cell survival, and (iii) identify and exploit mechanisms of treatment resistance.
Research Biography
Education
- M.D. Justus-Liebig-University of Giessen, Germany
- Ph.D. Institute of Physiological Chemistry, Justus-Liebig-University of Giessen, Germany
- Board Certified by the German Anatomical Society
- Habilitation in Anatomy and Reproductive Biology
Achievements
- Feodor-Lynen Research Fellowship Award, Alexander-von-Humboldt Foundation, Germany
- Honorary Professor of Shantou University Medical College, Shantou, China
- Terry Fox Research Institute (TFRI) Manitoba Lead in Adult Glioma
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Featured Publications
- Slow Off-Rate Modified Aptamer (SOMAmer) Proteomic Analysis of Patient-Derived Malignant Glioma Identifies Distinct Cellular Proteomes. Thanasupawat T, Glogowska A, Pascoe C, Krishnan SN, Munir M, Begum F, Beiko J, Krcek J, Del Bigio MR, Pitz M, Shen Y, Spicer V, Coombs KM, Wilkins J, Hombach-Klonisch S, Klonisch T.Int J Mol Sci. 2021 Sep 3;22(17):9566. doi: 10.3390/ijms22179566.PMID: 34502484
- Novel CTRP8-RXFP1-JAK3-STAT3 axis promotes Cdc42-dependent actin remodeling for enhanced filopodia formation and motility in human glioblastoma cells. Glogowska A, Thanasupawat T, Beiko J, Pitz M, Hombach-Klonisch S, Klonisch T.Mol Oncol. 2022 Jan;16(2):368-387. doi: 10.1002/1878-0261.12981. Epub 2021 Jun 18.PMID: 33960104
- HMGA2 as a functional antagonist of PARP1 inhibitors in tumor cells. Hombach-Klonisch S, Kalantari F, Medapati MR, Natarajan S, Krishnan SN, Kumar-Kanojia A, Thanasupawat T, Begum F, Xu FY, Hatch GM, Los M, Klonisch T.Mol Oncol. 2019 Feb;13(2):153-170. doi: 10.1002/1878-0261.12390. Epub 2018 Nov 28.PMID: 30289618
- C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance in human glioblastoma. Thanasupawat T, Glogowska A, Burg M, Krcek J, Beiko J, Pitz M, Zhang GJ, Hombach-Klonisch S, Klonisch T.Mol Oncol. 2018 Sep;12(9):1464-1479. doi: 10.1002/1878-0261.12349. Epub 2018 Aug 2.PMID: 29949238
- High Mobility Group A2 protects cancer cells against telomere dysfunction. Natarajan S, Begum F, Gim J, Wark L, Henderson D, Davie JR, Hombach-Klonisch S, Klonisch T.Oncotarget. 2016 Mar 15;7(11):12761-82. doi: 10.18632/oncotarget.6938.PMID: 26799419
- C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel interaction partner of relaxin receptor RXFP1 in human brain cancer cells. Glogowska A, Kunanuvat U, Stetefeld J, Patel TR, Thanasupawat T, Krcek J, Weber E, Wong GW, Del Bigio MR, Hoang-Vu C, Hombach-Klonisch S, Klonisch T.J Pathol. 2013 Dec;231(4):466-79. doi: 10.1002/path.4257.PMID: 24014093
