Research Discipline(s): Basic
Primary Title: Assistant Professor, Department of Human Anatomy and Cell Science, University of Manitoba
Additional Titles & Affiliations: Canada Research Chair in Cell Stress and Inflammation (Tier 2), Adjunct Scientist CancerCare Manitoba Research Institute
RESEARCH TOPICS
Cellular Stress Responses, Cell Death, Breast Cancer
Research Summary
Research in the Logue Lab focuses on cell stress responses. These pro-survival pathways are essential for the maintenance of cell health but when dysregulated can contribute to the progression of diseases including multiple forms of cancer. In our lab we focus on one stress response called the Unfolded Protein Response or UPR. We study the signaling pathways that control the UPR and ask how these pathways help promote cancer progression. One cancer we focus on is a form of breast cancer called Triple Negative Breast Cancer (TNBC). Unlike healthy cells, in TNBC cells the UPR is permanently switched on. Our research asks how sustained UPR activation supports TNBC progression and responsiveness to commonly used therapies such as chemotherapy. Answering these questions will (1) increase our basic understanding of TNBC and the pathways which support its progression and (2) help us answer if switching off the UPR would be a good therapeutic approach for the treatment of TNBC.
Goals
The Logue Lab research program focuses on cell stress responses and in particular one stress response called the Unfolded Protein Response (UPR). Our goals are to (1) understand the cellular signaling pathways that support the UPR and (2) investigate how inappropriate activation of the UPR promotes cancer progression.
Research Biography
Dr. Logue completed her undergraduate BSc (Hons) in Biochemistry followed by a Masters in Medical Science at the Queen’s University of Belfast, Northern Ireland. She then moved to the National University of Ireland, Galway to complete her PhD focused on endoplasmic reticulum stress induced cell death. Following her PhD, Dr. Logue completed postdoctoral training in the area of cell stress, cell death and inflammation. Dr. Logue's work has helped increase our fundamental understanding of the cell signaling pathways underpinning these essential cellular responses. In 2019, Dr. Logue joined the University of Manitoba, where her research program focuses on understanding the role of the Unfolded Protein Response in health and disease.
Achievements
- Canada Research Chair in Cell Stress and Inflammation (Tier 2)
- Science Foundation Ireland SIRG award
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Featured Publications
- Logue SE, Gorman AM, Samali A. New insights into IRE1a activation and function in anti-tumor immunity. J Cell Biol. 2022 Jun 6;221(6):e202205019.
- Madden EC, Gorman AM, Logue SE*, Samali A*. Tumour Cell Secretome in Chemoresistance and Tumour Recurrence. Trends in Cancer. 2020 Jun;6(6):489-505. *Joint Corresponding author
- Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β . Talty A, Deegan S, Ljujic M, Mnich K, Naicker SD, Quandt D, Zeng Q, Patterson JB, Gorman AM, Griffin MD, Samali A, Logue SE. Cell Death Dis. 2019 Aug 16;10(9):622.
- Madden E, Logue SE*, Healy SJ, Manie S, Samali A. The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance. Biol Cell. 2019 Jan;111(1):1-17. *Equal first author
- Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jäger R, Gorman AM, Samali A. Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhance response to chemotherapy. Nature Communications. 2018 Aug 15;9(1):3267
- Saveljeva S, Cleary P, Mnich K, Ayo A, Pakos-Zebruka K, Patterson J, Logue SE*, Samali A*. Endoplasmic Reticulum Stress-mediated Induction of Sestrin 2 potentiates cell survival. Oncotarget. 2016. 15;7(11):12254-66. *Joint Corresponding author
- Deegan S*, Saveljeva S*, Logue SE*, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. Autophagy. 2014;10(11):1921-36. * Equal First Author
- Afonina I, Tynan GA, Logue SE, Cullen SP, Lüthi AU, Lavell EC, Martin SJ. Granzyme B-dependent proteolysis acts as a switch to enhance the pro-inflammatory activity of IL-1α. Molecular Cell. 2011 Oct 21;44(2):265-78
