Research Discipline(s): Basic, Translational
Primary Title: Professor
Additional Titles & Affiliations: Tier 1 Canada Research Chair, University of Manitoba
RESEARCH TOPICS
Hematological, Solid Tumors
My goal is to translate my research findings to the clinic.
Research Summary
We study the nuclear architecture of the genome and how it relates to the onset and propagation of genomic instability in cancer. We identified mechanisms of nuclear remodelling in cancer and described structural biomarkers that, among other features, enable the stratification of disease stages, the patient’s risk assessment and treatment response.
Goals
To enable cancer precision medicine based on nuclear architecture
To develop treatments based on nuclear architecture and its dysfunction in cancer
Research Biography
See details at https://umanitoba.ca/medicine/faculty-staff/sabine-mai
Achievements
- Cognition Challenge Award (2013)
- YMCA Women of Distinction Nominee (2014)
- Women’s Executive Network (WXN) Top 100: Canada’s Most Powerful Women (2015)
- University of British Columbia (UBC) Science Co-op Supervisor Recognition Award (2017)
- Canada Research Chair Tier 1 (Genomic Instability and Nuclear Architecture in Cancer) (2018-2026)
-
Featured Publications
- Lima FOd, Freitas MO, Hamedani MK, Rangel-Pozzo A, Zhu X-D, Mai S. Consecutive inhibition of telomerase and alternative telomere lengthening pathway promotes Hodgkin’s Lymphoma cell death. Biomedicines. 2022 Sep 16;10(9):2299.
- Pozzo-Rangel A, Yu PLI, Lal S, Asbaghi Y, Sisdelli L, Tammur P, Tamm A, Punab M, Klewes L, Louis S, Knecht H, Olujohungbe A, Mai S. Telomere architecture correlates with aggressiveness in multiple myeloma. Cancers 2021. 13, 1969.
- Drachenberg D, Awe J, Rangel Pozzo A, Saranchuk J, Mai S. Advancing risk assessment in intermediate risk prostate cancer patients. Cancers 11, 855, 2019.
- Szczurek A, Klewes L, Xing J, Gourram A, Birk U, Knecht H, Dobrucki JW, Mai S, Cremer C. Imaging chromatin nanostructure with binding-activated localization microscopy based on DNA structure fluctuations. Nucleic Acids Res. 2017. May 5;45(8):e56.
- Sathitruangsak C, Righolt CH, Klewes L, Chang DT, Kotb R, Mai S. Distinct and shared three-dimensional chromosome organization patterns in lymohocytes, monocloncal gammopathy of undetermined significance and multiple myeloma. Int J Cancer. 15;140(2):400-410. 2017.
- Bronshtein I, Kepten E, Berezin S, Kanter I, Lindner M, Redwood AB, Mai S, Gonzalo S, Foisner R, Shav-Tal Y, Garini Y. Lamin A maintains genome organization in the eukaryotic nucleus. 2015 Nature Comm. 2015 Aug 24;6:8044.
- Lajoie V, Lemieux B, Sawan B, Lichtensztejn D, Lichtensztejn Z, Wellinger R, Mai S, Knecht H. LMP1 mediates multinuclearity through downregulation of shelterin proteins and formation of telomeric aggregates. Blood. 125 (13): 2101-2110. 2015 Jan 7.
- Gadji M, Awe JA, Rodrigues P, Kumar R, Houston D, Falcão PR, de Oliveira FM, Mai S. Profiling the Three-Dimensional Nuclear Telomeric Architecture in Myelodysplastic Syndrome and Acute Myeloid Leukemia defines patient subpopulations. Clinical Cancer Research 18(12):3293-304. 2012.
