Michael Charette, PhD

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Michael Charette, PhD

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Research Discipline(s): Basic

Primary Title: Assistant Professor

Additional Titles & Affiliations: Brandon University, Children's Hospital Research Institute of Manitoba (CHRIM)


Ribosome Assembly Disorders/Ribosomopathies

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Research Summary

Research in the Charette Lab uses yeast models to study the function and regulation of the SSU processome in ribosome assembly in both healthy and disease states. Ribosome assembly is needed for cell growth and is dysregulated in cancer. A number of ribosome assembly disorders (called ribosomopathies) result in the mis-assembly of ribosomes which is linked to cancer. These include Diamond-Blackfan anemia and a number of other rare genetic diseases and their associated cancers. We are specifically interested in identifying the function of the SSU processome protein Emg1, which includes a sequence variant that causes Bowen-Conradi Syndrome. Emg1 is of interest in cancer because it is required for the assembly of the mRNA decoding center of the ribosome P-site which is critical to the efficient and accurate translation of mRNA into protein. We are also interested in determining the role of the protein kinase CK2 complex in the regulation of SSU processome function and ribosome assembly in normal and cancer growth.


"Determine the role of Emg1 in the assembly of the ""hypermodified U"" of ribosome SSU P-site.
Quantify the protein translation error rate in ribosome assembly disorders.
Identify the role of the protein kinase CK2 in the regulation of ribosome assembly."

Research Biography

Dr. Charette completed his undergraduate thesis in Molecular and Cellular Biology at Dalhousie University under the supervision of Melanie Dobson, DPhil. He then pursued a PhD in Biochemistry and Molecular Biology also at Dalhousie with Michael W. Gray, PhD. He was then a Post-Doctoral Fellow in the Departments of Therapeutic Radiology and of Molecular Biophysics and Biochemistry at the Yale School of Medicine in the lab of Susan J. Baserga, MD/PhD. He has been at Brandon University since 2014 where he is a tenured Assistant Professor of Biochemistry in the Department of Chemistry, a member of the Children’s Hospital Research Institute of Manitoba (CHRIM) and of the CancerCare Manitoba Research Institute. Research in the Charette lab is funded by NSERC-DG, a joint CFI-JELF, CHRIM, CCMBRI, and Brandon University.


  • CHIR PhD student fellowship
  • Ruth L. Kirschstein/NIH Post-Doctoral Fellowship
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    Featured Publications

    • https://pubmed.ncbi.nlm.nih.gov/36212518/
    • https://pubmed.ncbi.nlm.nih.gov/29054886/
    • https://pubmed.ncbi.nlm.nih.gov/25877921/
    • https://pubmed.ncbi.nlm.nih.gov/22902402/
    • https://pubmed.ncbi.nlm.nih.gov/21318072/
    • https://pubmed.ncbi.nlm.nih.gov/20884785/
    • https://pubmed.ncbi.nlm.nih.gov/17051219/
    • https://pubmed.ncbi.nlm.nih.gov/10902565/

    Publications List

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