Research Discipline(s): Translational, Clinical, Health Services, Quality-of-Life, Patient-Reported Outcomes
Primary Title: Associate Professor, Department of Surgery
Additional Titles & Affiliations: Medical Director, Wilf Taillieu Thoracic Clinic & Endoscopy Unit Research Director, Thoracic Surgery and Surgical Peri-Operative Research Team (SPORT) Adjunct Scientist, CancerCare Manitoba Research Institute Adjunct Professor, Department of Physiology & Pathophysiology
RESEARCH TOPICS
Lung Cancer, Inflammation and Malignancy, Esophageal Cancer, Patient-Reported Outcomes
Health Sciences Centre
820 Sherbrook St, GE-611
Winnipeg, MB R3A 1R9
Canada
My program of research in esophageal and lung cancer brings together elements of surgical quality, patient quality of life, oncologic outcomes and health resource utilization with the ultimate goal of identifying the right treatment for the right patient at the right time.
Research Summary
Dr. Kidane has a research interest in peri-operative care, with a major interest in lung-protective ventilation during thoracic surgery. His translational research program centers on understanding the role of intraoperative inflammation in development of short and long-term complications as well as cancer recurrence. He also has a research interest in health services and outcomes research as it relates to esophageal and lung cancer. The research centers on health resource utilization and patient quality of life. Esophageal cancer is a devastating illness with historically poor survival; furthermore, the treatment of esophageal cancer can be difficult and cause significant reductions in the quality of life. Dr. Kidane’s program of research in esophageal cancer brings together elements of surgical quality, patient quality of life, oncologic outcomes and health resource utilization with the ultimate goal of identifying the right treatment for the right patient at the right time.
Goals
Dr Kidane's research goals are:
- To make cancer surgery as safe as possible by understanding and treating the inflammatory insults that occur peri-operatively
- To make cancer surgery as effective as possible by eliminating peri-operative inflammatory insults that increase risks of cancer recurrence or metastasis
- To make cancer surgery as minimally invasive as possible by combining different therapies with incision-less endoscopic therapies
Research Biography
Dr. Kidane completed his undergraduate training at the University of Toronto, obtaining an Honours Bachelor of Science in Laboratory Medicine and Pathobiology. He then completed his MD at the University of Toronto and his General Surgery Residency at Western University. He completed thoracic surgery residency at the University of Toronto. He completed his Master of Science at McMaster University.
His research interests in the inflammatory consequences of one-lung ventilation during lung surgery sparked an organic expansion of his research focus into how peri-operative inflammation can influence development of cancer recurrence. This has resulted in multi-disciplinary collaborations with co-investigators in Physiology, Anatomy, Biomedical Engineering and Community Health Sciences.
Achievements
- List coming soon
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Featured Publications
- Kidane B, Spicer J, Kim JO, Fiset PO, Abdulkarim B, Malthaner R, Palma D. SABR-BRIDGE: Stereotactic ABlative Radiotherapy Before Resection to AvoId Delay for Early-Stage LunG Cancer or OligomEts During the COVID-19 Pandemic. Front Oncol. 2020 Sep 25;10:580189. doi: 10.3389/fonc.2020.580189. PMID: 33072612; PMCID: PMC7544973.
- Hirpara DH, Kidane B, Louie AV, Zuk V, Darling G, Rousseau M, Chesney T, Coburn N, Hallet J; REcovery after Surgical Therapy for Older adults REsearch – Cancer (RESTORE-C) group. Long-Term Dependency in Older Adults after Surgery or Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer. Ann Surg. 2022 Aug 15. doi: 10.1097/SLA.0000000000005660. Epub ahead of print. PMID: 35968895.
- Kidane B, Jacob N, Bruinooge A, Shen YC, Keshavjee S, dePerrot ME, Pierre AF, Yasufuku K, Cypel M, Waddell TK, Darling GE. Postoperative but not intraoperative transfusions are associated with respiratory failure after pneumonectomy. Eur J Cardiothorac Surg. 2020 Nov 1;58(5):1004-1009. doi: 10.1093/ejcts/ezaa107. PMID: 32303064.
- Kidane B, Kaaki S, Hirpara DH, Shen YC, Bassili A, Allison F, Waddell TK, Darling GE. Emergency department use is high after esophagectomy and feeding tube problems are the biggest culprit. J Thorac Cardiovasc Surg. 2018 Dec;156(6):2340-2348. doi: 10.1016/j.jtcvs.2018.07.100. Epub 2018 Sep 7. PMID: 30309674.
- Kidane B, Jacob B, Gupta V, Peel J, Saskin R, Waddell TK, Darling GE. Medium and long-term emergency department utilization after oesophagectomy: a population-based analysis. Eur J Cardiothorac Surg. 2018 Oct 1;54(4):683-688. doi: 10.1093/ejcts/ezy155. PMID: 29648637.
- Kidane B, Sulman J, Xu W, Kong QQ, Wong R, Knox JJ, Darling GE. Baseline measure of health-related quality of life (Functional Assessment of Cancer Therapy-Esophagus) is associated with overall survival in patients with esophageal cancer. J Thorac Cardiovasc Surg. 2016 Jun;151(6):1571-80. doi: 10.1016/j.jtcvs.2016.01.052. Epub 2016 Feb 24. PMID: 27016795.
- Ahmed N, Kidane B, Wang L, Nugent Z, Moldovan N, McElrea A, Shariati-Ievari S, Qing G, Tan L, Buduhan G, Srinathan SK, Meyers R, Aliani M. Metabolic Alterations in Sputum and Exhaled Breath Condensate of Early Stage Non-Small Cell Lung Cancer Patients After Surgical Resection: A Pilot Study. Front Oncol. 2022 Jun 3;12:874964. doi: 10.3389/fonc.2022.874964. PMID: 35719971; PMCID: PMC9204221.
