Research Discipline(s): Basic, Translational
Primary Title: Professor
Additional Titles & Affiliations: Adjunct Senior Scientist, CCMB
RESEARCH TOPICS
Colorectal Cancer, Breast Cancer, Predictive Diagnostic, Prognostic Diagnostic, Companion Diagnostic and Therapeutics
Developing early detection methods and treatment for hard-to-treat cancers!
Research Summary
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My translational research has led to the identification of novel mechanisms associated with metastases, the basis of our core technology platform that has resulted in unique molecular signatures specific to different cancer types. Based on this platform technology, we have developed a screening test for colorectal cancer (CRC) and diagnostics for breast cancers.
CRC is most preventable through screening and is highly curable if detected early. Yet is still the second leading cause of death due to cancer. The unpleasant nature of fecal-based tests or lack of resources for invasive tests results in poor compliance for CRC screening. We have developed a simple blood test for CRC screening and currently testing its efficacy.
Another area of my research is to develop simple predictive, prognostic, and companion diagnostics for hard-to-treat cancers such as triple-negative breast cancer. We have identified novel therapeutic targets for metastatic cancers through our platform technology and are currently developing small molecules as drug candidates.
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Goals
The overreaching goal of my research is to develop targeted therapies for hard-to-treat metastatic cancers and companion diagnostics to select patients benefiting from such therapies.
Research Biography
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I hold a PhD in MedChem from Banaras Hindu University, India. I was awarded a CIHR postdoctoral fellowship in 2004 for my work on aberrations in signal transduction and lipidic modifier in cancer.
I was appointed Assistant Professor at the University of Winnipeg in 2010. I joined CancerCare Manitoba as an Adjunct Scientist in 2016.
Currently, I am a full professor at the department of biology at the University of Winnipeg and a senior adjunct scientist at the CancerCare Manitoba Research Institute.
"Achievements
- List coming soon
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Featured Publications
- N-myristoyltransferase 2–based Blood Test for the Detection of Colorectal Adenomatous Polyps and Cancer: Rathinagopal, Tharmini; Bhanot, Shiv; Yegrov, Sergey; Min, Jordan; Hu, Nan PhD; Fang, John MD; Greene, Tom H; Varma Shrivastav, Shailly; Singh, Harminder; Shrivastav, Anuraag. Annals of Surgery Open 3(1):p e117, March 2022.
- Investigation of Novel Regulation of N-myristoyltransferase by Mammalian Target of Rapamycin in Breast Cancer Cells. Jacquier M, Kuriakose S, Bhardwaj A, Zhang Y, Shrivastav A, Portet S, Varma Shrivastav S. Sci Rep. 2018 Aug 28;8(1):12969. doi: 10.1038/s41598-018-30447-0.
- Myristoylation: An Important Protein Modification in the Immune Response. Udenwobele DI, Su RC, Good SV, Ball TB, Varma Shrivastav S, Shrivastav A. Front Immunol. 2017 Jun 30;8:751. doi: 10.3389/fimmu.2017.00751
- The mechanistic target for rapamycin pathway is related to the phosphorylation score for estrogen receptor-α in human breast tumors in vivo. Shrivastav A, Bruce M, Jaksic D, Bader T, Seekallu S, Penner C, Nugent Z, Watson P, Murphy L. Breast Cancer Res. 2014 May 22;16(3):R49.
- Overexpression of Akt/PKB modulates N-myristoyltransferase activity in cancer cells. Shrivastav A, Varma S, Senger A, Khandelwal RL, Carlsen S, Sharma RK. J Pathol. 2009 Jul;218(3):391-8. doi: 10.1002/path.2550.
- Requirement of N-myristoyltransferase 1 in the development of monocytic lineage. Shrivastav A, Varma S, Lawman Z, Yang SH, Ritchie SA, Bonham K, Singh SM, Saxena A, Sharma RK. J Immunol. 2008 Jan 15;180(2):1019-28. doi: 10.4049/jimmunol.180.2.1019.
- N-myristoyltransferase: a potential novel diagnostic marker for colon cancer. Shrivastav A, Varma S, Saxena A, DeCoteau J, Sharma RK. J Transl Med. 2007 Nov 16;5:58. doi: 10.1186/1479-5876-5-58.
- Synthesis, characterization and antitumor studies of transition metal complexes of o-hydroxydithiobenzoate. Shrivastav A, Singh NK, Srivastava G. Bioorg Med Chem. 2002 Aug;10(8):2693-704. doi: 10.1016/s0968-0896(02)00087-1.
